Publications

• Mack SJ, Schefzyk D, Milius RP, Maiers M, Hollenbach JA, Pollack J, Heuer ML, Gragert L, Spellman SR, Guethlein LA, Schneider J, Bochtler W, Eberhard HP, Robinson J, Marsh SGE, Schmidt AH, Hofmann JA, Sauter J (2023) Genotype List String 1.1: Extending the Genotype List String Grammar for Describing HLA and Killer-cell Immunoglobulin-like Receptor Genotypes. HLA: Immune Response Genetics DOI: 10.1111/tan.15126

• Dasariraju S, Gragert L, Wager G, McCullough K, Brown NK, Kamoun M, Urbanowicz R. (2023) HLA Amino Acid Mismatch-Based Risk Stratification of Kidney Allograft Failure Using a Novel Machine Learning Algorithm. Journal of Biomedical Informatics Available online 27 April 2023, 104374. DOI: 10.1016/j.jbi.2023.104374.

• Ansbacher-Feldman Z, Israeli S, Maiers M, Gragert L, De Santis D, Israeli M, Louzoun Y. (2023) GRAMM – a new method for analysis of HLA in families. HLA: Immune Response Genetics DOI: 10.1111/tan.15075

• Nilsson J, Kaabinejadian S, Yari H, Peters B, Barra C, Gragert L, Hildebrand W, Nielsen M. (2023) Machine learning reveals limited contribution of trans-only encoded variants to the HLA-DQ immunopeptidome by accurate and comprehensive HLA-DQ antigen presentation prediction. Communications Biology 6(1) 442.

• Narayan R, Niroula A, Wang T, Kuxhausen M, He M, Meyer E, Chen YB, Bhatt VR, Beitinjaneh A, Nishihori T, Sharma A, Brown VI, Kamoun M, Diaz MA, Abid MB, Askar M, Kanakry CG, Gragert L, Bolon YT, Marsh SGE, Gadalla SM, Paczesny S, Spellman S, Lee SJ (2023) HLA Class I genotype is associated with relapse risk after allogeneic stem cell transplantation for NPM1-mutated AML. Transplantation and Cellular Therapy DOI: 10.1016/j.jtct.2023.03.027.

• Kim JJ, Fichtner A, Copley HC, Gragert L, Süsal C, Strologo LD, Oh J, Pape L, Weber LT, Weitz M, König JC, Krupka K, T Burkhard, Kosmoliaptsis V (2023) Molecular HLA mismatching for prediction of primary humoral alloimmunity and graft function deterioration in paediatric kidney transplantation. Frontiers in Immunology 14:1092335.

• Gragert L, Spellman S, Shaw B, Maiers M. (2023) Unrelated Stem Cell Donor HLA Match Likelihoods in the US Registry Incorporating HLA-DPB1 Permissible Mismatching. Transplantation and Cellular Therapy 29(4) 244-252.

• Stahl M, Li Q, Lynch K, Koletzko S, Mehta P, Gragert L, Norris J, Aronsson C, Lindfors K,  Kurppa K, Ilonen J, Krischer J, Alkolkar B, She J, Ziegler A, Toppari J, Rewers M, Agardh D, Hagopian, W, Liu E, and the TEDDY Study Group. (2022) Incidence of Pediatric Celiac Disease Varies by Region. American Journal of Gastroenterology 118(3):539-545.

• Olson T, Frost BF, Duke JL, Dribus M, Xie HM, Prudowsky ZD, Furutani E, Gudera J, Shah Y, Ferriola D, Xu E, He M, Zheng S, Nijim S, Lin P, Xu C, Nakano T, Oved JH, Carreno BM, Lee SJ, Monos DS, Shimamura A, Bertuch AA, Gragert
  L, Spellman SR, Babushok D (2022) Pathogenicity and impact of HLA class I alleles in aplastic anemia patients of different ethnicities. JCI Insight e163040.

• Gragert L, Kadatz M, Alcorn J, Stewart D, Gill J, Liwski R, Gebel H, Gill J, Lan J. (2022) ABO-Adjusted Calculated Panel Reactive Antibody (cPRA): A Unified Metric for Immunologic Compatibility in Kidney Transplantation. American Journal of Transplantation. doi: 10.1111/ajt.17175. PMID: 35975734

 

• Rushakoff J, Gragert L, Pando MJ, Huang E, Stewart D, Lindblad K, Zhang X, Patel JK, Kobashigawa J, Kransdorf EP. (2022) HLA Homozygosity and Sensitization in Kidney Transplant Candidates. Transplantation Direct 8, e1312. PMID: 35415215

 

• Schindler E, Dribus M, Duffy BF, Hock K, Farnsworth CW, Gragert L, Liu C. (2021) Human leukocyte antigen genetic polymorphism in patients with Coronavirus Disease 2019 in Midwestern United States. HLA 98(4): 370-379. PMID: 34338446

• Copley H, Gragert L, Leach A, Kosmoliaptsis, V. (2021) Influence of HLA class II polymorphism on predicted cellular immunity against SARS-CoV-2 at the population and individual level. Frontiers in Immunology 12:6-8. PMID: 34349756

 

• Israeli S, Gragert L, Maiers M, Louzoun Y. (2021) HLA Haplotype Frequency Estimation for Heterogeneous Populations Using a Graph-Based Imputation Algorithm. Human Immunology 82(10) 746-757. PMID: 34325951

 

• Sajulga R, Madbouly A, Fingerson S, Gragert L, Bashyal P, Bolon YT, Maiers M. (2021) Predicting HLA-DPB1 Permissive Probabilities through a DPB1 Prediction Service towards the Optimization of HCT Donor Selection. Human Immunology 82(21) 903-911. PMID: 34362573

 

• Mayor N, Wang T, Lee SJ, Kuxhausen M, Vierra-Green C, Barker DJ, Auletta J, Bhatt VR, Gadalla SM, Gragert L, Inamoto Y, Morris GP, Paczesny S, Reshef R, Ringden O, Shaw BE, Shaw P, Spellman S, Marsh SGE. (2021) Impact of Previously Unrecognized HLA Mismatches Using Ultrahigh Resolution Typing in Unrelated Donor Hematopoietic Cell Transplantation. Journal of Clinical Oncology 39:21 2397-2409. PMID: 33835855

 

• Story, MS, Wang T, Bhatt VR, Battiwalla M, Badawy SM, Kamoun M, Gragert L, Brown V, Baxter-Lowe LA, Marsh SGE, Gadalla SM, Schetelig J, Mytilineos J, Miklos D, Waller E, Kuxhausen M, Spellman S, Lee S, Armistead PM (2021) Genetics of HLA peptide presentation, and impact on outcomes in HLA-matched allo-HCT. Transplantation and Cellular Therapy 27:7 591-599. PMID: 33882342

 

• Kransdorf E, Pando M, Stewart D, Lindblad K, Patel J, Kim I, Zhang X, Maiers M, Kobashigawa J, Gragert L. (2021) Stem Cell Donor HLA Typing Improves CPRA in Kidney Allocation. American Journal of Transplantation 21(1) 138-147. PMID: 32558252

 

• Sullivan, H, Gragert L, Smith G, Lindblad K, Gebel H, Bray R. (2020) A simple electronic tool for comparing amino acid sequences of HLA-DPB1 alleles. Human Immunology DOI: 10.1016/j.humimm.2020.06.011.

 

• Kaur N, Pinelli D, Kransdorf E, Pando M, Smith G, Murphey C, Kamoun M, Bray R, Tambur A, Gragert L. (2020) A blueprint for electronic utilization of ambiguous molecular HLA typing data in organ allocation systems and virtual crossmatch. Human Immunology 81(2-3) 65-72. PMID: 32057520

 

• Lobkovsky A, Levi L, Wolf Y, Maiers M, Gragert L, Alter I, Louzoun Y, Koonin E. (2019) Multiplicative fitness, rapid haplotype discovery and fitness decay explain evolution of human MHC. Proceedings of the National Academy of Sciences 116(28): 14098-14104. PMID: 31227609

 

• Zhong C, Gragert L, Maiers M, Hill BT, Garcia-Gomez J, Gendzekhadze K, Senitzer D, Song J, Weisenburger D, Goldstein L, Wang S. (2019) The association between HLA and non-Hodgkin lymphoma subtypes, among a transplant-indicated population. Leukemia & Lymphoma 60(12): 2899-2908. PMID: 31215275

 

• Allan D, Kiernan J, Gragert L, Dibdin N, Bartlett D, Campbell T, Mostert K, Halpenny M, Ganz K, Maiers M, Petraszko T, Elmoazzen H. Reducing ethnic disparity in access to high-quality HLA-matched cord blood units for transplantation: analysis of the Canadian Blood Services’ Cord Blood Bank inventory . Transfusion.  2019 Apr 19. doi: 10.1111/trf.15313. PMID: 31002398.

 

• Maiers M, Halagan M, Gragert L, Bashyal P, Schneider J, Lutsker P, Louzoun Y, Gan R GRIMM : GRaph IMputation and Matching for HLA Genotypes . Bioinformatics. 2019; doi: 10.1093/bioinformatics/btz050; PMID: 30689784.

 

• Kaur N, Kransdorf EP, Pando MJ, Maiers M, Ray B, Lee JH, Lalli P, Murphey C, Bray R, Gragert L. Mapping molecular HLA typing data to UNOS antigen equivalents for improved virtual crossmatch. Human Immunology. 2018 https://doi.org/10.1016/J.HUMIMM.2018.08.002;  PMID: 30118777 

 

• Louzoun Y, Alter I, Gragert L, Albrecht M, Maiers M. Modeling coverage gaps in haplotype frequencies via Bayesian inference to improve stem cell donor selection . Immunogenetics. 2017;  PMID: 29124304

 

• Kransdorf EP, Pando MJ, Gragert L, Kaplan B. HLA Population Genetics in Solid Organ Transplantation . Transplantation. 2017; 101(9):1971-1976. PMID: 28832450

 

• Alter I, Gragert L, Fingerson S, Maiers M, Louzoun Y. HLA class I haplotype diversity is consistent with selection for frequent existing haplotypes . PLoS computational biology. 2017; 13(8):e1005693. PMID: 28846675, PMCID: PMC5590998

 

• Beksac M, Gragert L, Fingerson S, Maiers M, Zhang MJ, Albrecht M, Zhong X, Cozen W, Dispenzieri A, Lonial S, Hari P. HLA polymorphism and risk of multiple myeloma. Leukemia. 2016; 30(11):2260-2264. PMID: 27461064, PMCID: PMC5134914

 

• Dehn J, Setterholm M, Buck K, Kempenich J, Beduhn B, Gragert L, Madbouly A, Fingerson S, Maiers M. HapLogic: A Predictive Human Leukocyte Antigen-Matching Algorithm to Enhance Rapid Identification of the Optimal Unrelated Hematopoietic Stem Cell Sources for Transplantation . Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2016; 22(11):2038-2046. PMID: 27496216

 

• Paunić V, Gragert L, Schneider J, Müller C, Maiers M. Charting improvements in US registry HLA typing ambiguity using a typing resolution score . Human immunology. 2016; 77(7):542-9.  PMID: 27163154

 

• Bochtler W, Gragert L, Patel ZI, Robinson J, Steiner D, Hofmann JA, Pingel J, Baouz A, Melis A, Schneider J, Eberhard HP, Oudshoorn M, Marsh SG, Maiers M, Müller CR. A comparative reference study for the validation of HLA-matching algorithms in the search for allogeneic hematopoietic stem cell donors and cord blood units . HLA. 2016; 87(6):439-48.  PMID: 27219013, PMCID: PMC5089599

 

• Torikai H, Mi T, Gragert L, Maiers M, Najjar A, Ang S, Maiti S, Dai J, Switzer KC, Huls H, Dulay GP, Reik A, Rebar EJ, Holmes MC, Gregory PD, Champlin RE, Shpall EJ, Cooper LJ. Genetic editing of HLA expression in hematopoietic stem cells to broaden their human application . Scientific reports. 2016; 6:21757. PMID: 26902653, PMCID: PMC4763194

 

• Slater N, Louzoun Y, Gragert L, Maiers M, Chatterjee A, Albrecht M. Power laws for heavy-tailed distributions: modeling allele and haplotype diversity for the national marrow donor program . PLoS computational biology. 2015; 11(4):e1004204. PMID: 25901749, PMCID: PMC4406525

 

• Petz LD, Burnett JC, Li H, Li S, Tonai R, Bakalinskaya M, Shpall EJ, Armitage S, Kurtzberg J, Regan DM, Clark P, Querol S, Gutman JA, Spellman SR, Gragert L, Rossi JJ. Progress toward curing HIV infection with hematopoietic cell transplantation . Stem cells and cloning : advances and applications. 2015; 8:109-16. PMID: 26251620, PMCID: PMC4524463

 

• Gragert L, Fingerson S, Albrecht M, Maiers M, Kalaycio M, Hill BT. Fine-mapping of HLA associations with chronic lymphocytic leukemia in US populations . Blood. 2014; 124(17):2657-65. PMID: 25232063, PMCID: PMC4208281

 

• Madbouly A, Gragert L, Freeman J, Leahy N, Gourraud PA, Hollenbach JA, Kamoun M, Fernandez-Vina M, Maiers M. Validation of statistical imputation of allele-level multilocus phased genotypes from ambiguous HLA assignments. Tissue antigens. 2014; 84(3):285-92. PMID: 25040134

 

• Gragert L, Eapen M, Williams E, Freeman J, Spellman S, Baitty R, Hartzman R, Rizzo JD, Horowitz M, Confer D, Maiers M. HLA match likelihoods for hematopoietic stem-cell grafts in the U.S. registry. The New England journal of medicine. 2014; 371(4):339-48.  PMID: 25054717

 

• Gragert L, Madbouly A, Freeman J, Maiers M. Six-locus high resolution HLA haplotype frequencies derived from mixed-resolution DNA typing for the entire US donor registry . Human immunology. 2013; 74(10):1313-20.  PMID: 23806270

 

• Eberhard HP, Madbouly AS, Gourraud PA, Balère ML, Feldmann U, Gragert L, Torres HM, Pingel J, Schmidt AH, Steiner D, van der Zanden HG, Oudshoorn M, Marsh SG, Maiers M, Müller CR. Comparative validation of computer programs for haplotype frequency estimation from donor registry data . Tissue antigens. 2013; 82(2):93-105.  PMID: 23849067

 

• Milius RP, Mack SJ, Hollenbach JA, Pollack J, Heuer ML, Gragert L, Spellman S, Guethlein LA, Trachtenberg EA, Cooley S, Bochtler W, Mueller CR, Robinson J, Marsh SG, Maiers M. Genotype List String: a grammar for describing HLA and KIR genotyping results in a text string . Tissue antigens. 2013; 82(2):106-12.PMID: 23849068, PMCID: PMC3715123

 

• Petz LD, Redei I, Bryson Y, Regan D, Kurtzberg J, Shpall E, Gutman J, Querol S, Clark P, Tonai R, Santos S, Bravo A, Spellman S, Gragert L, Rossi J, Li S, Li H, Senitzer D, Zaia J, Rosenthal J, Forman S, Chow R. Hematopoietic cell transplantation with cord blood for cure of HIV infections . Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2013; 19(3):393-7.   PMID: 23089564, PMCID: PMC4651173

 

• Maiers M, Gragert L, Madbouly A, Steiner D, Marsh SG, Gourraud PA, Oudshoorn M, van der Zanden H, Schmidt AH, Pingel J, Hofmann J, Müller C, Eberhard HP. 16(th) IHIW: global analysis of registry HLA haplotypes from 20 million individuals: report from the IHIW Registry Diversity Group. International journal of immunogenetics. 2013; 40(1):66-71. PMID: 23280139, PMCID: PMC3561701

 

• Hollenbach JA, Madbouly A, Gragert L, Vierra-Green C, Flesch S, Spellman S, Begovich A, Noreen H, Trachtenberg E, Williams T, Yu N, Shaw B, Fleischhauer K, Fernandez-Vina M, Maiers M. A combined DPA1~DPB1 amino acid epitope is the primary unit of selection on the HLA-DP heterodimer . Immunogenetics. 2012; 64(8):559-69. PMID: 22526601, PMCID: PMC3395342

 

• Klitz W, Gragert L, Trachtenberg E. Spectrum of HLA associations: the case of medically refractory pediatric acute lymphoblastic leukemia . Immunogenetics. 2012; 64(6):409-19.  PMID: 22350167, PMCID: PMC3349849

 

• Paunić V, Gragert L, Madbouly A, Freeman J, Maiers M. Measuring ambiguity in HLA typing methods. PloS one. 2012; 7(8):e43585.  PMID: 22952712, PMCID: PMC3430707

 

• Abi-Rached L, Jobin MJ, Kulkarni S, McWhinnie A, Dalva K, Gragert L, Babrzadeh F, Gharizadeh B, Luo M, Plummer FA, Kimani J, Carrington M, Middleton D, Rajalingam R, Beksac M, Marsh SG, Maiers M, Guethlein LA, Tavoularis S, Little AM, Green RE, Norman PJ, Parham P. The shaping of modern human immune systems by multiregional admixture with archaic humans . Science (New York, N.Y.). 2011; 334(6052):89-94.  PMID: 21868630, PMCID: PMC3677943

 

• Cord Blood: Biology, Transplantation, Banking, and Regulation. Petz LD, Spellman S, Gragert L.Broxmeyer H, editor. Bethesda, MD: AABB Press; 2011. Chapter 32, The Underutilization of Cord Blood Transplantation: Extent of the Problem, Causes, and Methods of Improvement; p.557-584. 714p.

 

• Klitz W, Gragert L, Maiers M, Fernandez-Viña M, Ben-Naeh Y, Benedek G, Brautbar C, Israel S. Genetic differentiation of Jewish populations . Tissue antigens. 2010; 76(6):442-58. PMID: 20860586

 

• Klitz W, Gragert L, Maiers M, Tu B, Lazaro A, Yang R, Xu Q, Masaberg C, Ng J, Hurley CK. Four-locus high-resolution HLA typing in a sample of Mexican Americans. Tissue antigens. 2009; 74(6):508-13.  PMID: 19845916, PMCID: PMC3485641

 

• Klitz W, Maiers M, Gragert L. Re-creation of the genetic composition of a founder population. Human genetics. 2008; 124(4):417-21.  PMID: 18820949

 

• Howard DH, Meltzer D, Kollman C, Maiers M, Logan B, Gragert L, Setterholm M, Horowitz MM. Use of cost-effectiveness analysis to determine inventory size for a national cord blood bank. Medical decision making : an international journal of the Society for Medical Decision Making. 2008; 28(2):243-53. PMID: 18349441

 

• Kollman C, Maiers M, Gragert L, Müller C, Setterholm M, Oudshoorn M, Hurley CK. Estimation of HLA-A, -B, -DRB1 haplotype frequencies using mixed resolution data from a National Registry with selective retyping of volunteers . Human immunology. 2007; 68(12):950-8. PMID: 18191722

 

• Maiers M, Gragert L, Klitz W. High-resolution HLA alleles and haplotypes in the United States population. Human immunology. 2007; 68(9):779-88.  PMID: 17869653

 

• Cord Blood – Establishing a National Hematopoietic Stem Cell Bank Program Howard DH, Maiers M, Kollman C, Logan B, Gragert L, Setterholm M. Meyer EA, Hanna K, Gebbie K, editors. Washington, DC: Institute of Medicine of the National Academies: The National Academies Press; 2005. Chapter Appendix E, A Cost-Benefit Analysis of Increasing Cord Blood Inventory Levels; p.221-241. 314p.

 

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