On January 26, 2023, an updated metric for HLA antibody sensitization for the US organ allocation system was released by the United Network for Organ Sharing (UNOS). Under a UNOS contract, our laboratory developed the new reference panel for the calculated panel reactive antibody (CPRA) metric using a dataset of over 2 million high resolution HLA genotypes from the National Marrow Donor Program registry. The CPRA metric is used to determine organ allocation points and priority to ensure equity for highly sensitized transplant candidates who have antibodies against HLA. This updated added the DQA1, DPA1, and DPB1 loci and allowed for allele-specific antibodies to contribute to CPRA. This was the result of an excellent collaboration and data sharing between the stem cell transplant and organ transplant fields.
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